All Creatures Great and Small is making a triumphant return to Channel 5, bringing back all the beloved characters including Nicholas Ralph as James Herriot and Samuel West as Siegfried Farnon.
The first episode, dubbed Gathering the Flock, showcases James and Tristan (portrayed by Callum Woodhouse) taking drastic measures after witnessing Siegfried's wild and disorderly conduct, with sometouching behind-the-scenes moments.
Anna Madeley reprises her role as Mrs Hall, alongside Rachel Shenton as James's wife Helen. Tony Pitts and Imogen Clawson also make a comeback as Helen's father and sister, Richard and Jenny.
The sixth series will also welcome back Patricia Hodge as Mrs Pumphrey and Mollie Winnard as Maggie.
Here's everything you need to know about the guest stars for the first episode of the sixth series.
READ MORE: All Creatures Great and Small star confirms character's exit in series 6 update
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Wayne Foskett joins the cast for the opening episode. The 61 year old English actor is renowned for his roles in Merlin, Silent Witness and Midsomer Murders.
He's also an avid artist and has showcased his works at the Jardiniere art exhibition.
Fans might also recognise him as Richard Stark from Game of Thrones or as Tom in Lightfields.
Jimmy Herriot - Thomas RichesJames's son Jimmy is portrayed by Thomas Riches, but little is known about the young star at this point.
Susan, an acquaintance of Siegfried's, is played by Lucy-Jo Hudson, a 42 year old actress hailing from Leeds.
She's the sister of rugby league player Ryan Hudson and was previously married to Coronation Street actor Alan Halsall, who portrays Tyrone Dobbs, until 2018.
The mum-of-two is recognised for her roles as Katy Harris in Coronation Street, Rosie Trevanion in Wild at Heart and Donna-Marie Quinn in Hollyoaks.
Rosie Herriot - Arlie and Autumn DoyleArlie and Autumn Doyle join the cast as James and Helen's daughter Rosie, but little is known about these young twins.

Siena Marsden joins the cast as Mary, Edward's daughter, although not much is known about this young actress yet.
Edward Hall - Conor DeaneConor Deane returns as Mrs Hall's son Edward, and he is also known for his roles as Fred Holdsworth in The Hardacres and Kyre Branson in Sherwood.
His other credits include Ridley, Happy Valley and What It Feels Like for a Girl.
All Creatures Great and Small airs on Channel 5 on September 25 at 9pm
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